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You are here -- Pharma Intermediates -- Glibenclamide Sulfonamide

Glibenclamide Sulfonamide

glipizide
CAS No. 16673-34-00
Chemical Name 5-chloro-2-methoxy-n- [2-(4sulfamoylphenyl) Ethyl]benzamide
Molecular Formula C16H17CIN2O4S
Molecular Weight 368.83518
End Use Intermediate for the following drug :-
Glibenclamide (CAS No 10238-21-8 )
Therapeutic Cat. Of This Drug :- Antidiabetic

Product Specifications

Description White to yellowish crystalline powder
Melting Range 2110C – 2160C
Appearance of Solution 2.5 % solution in DMF is clear without any deposits
Chloride NMT 0.2 %
LOD NMT 1.0 %
Assay By
UV Spectrophotometer
96.5 to 102.5 % w/w on Dried Basis
Related Substance TLC method
by HPLC
(for USV LTD only)
1) Ortho Isometer NMT 1 %
2) Meta Isometer NMT 2 %
3) Other imp. NMT 2 %
4) Total imp. NMT 5 %
Optional : only to be tested befor USV dipatch
HPLC
(by Aventis method )

By product single 0.5%
impurity at 1.22<- 0.5%
Sum of all byproducts <-1.0%
Optional - Only to be tested before Aventis dispatch